Published Research
InterX Clinical Studies
We recognize the need for a higher level of proof when it comes to choosing the right treatment options for your patients. That's why we want to highlight what sets InterX apart from other therapies - our certifications and clinical studies. InterX is backed by rigorous research and testing, making it a reliable and trusted choice for healthcare professionals like you. Our certifications ensure that our devices meet the highest standards of quality and safety. With InterX, you can have confidence in the science behind our therapy, allowing you to provide the best possible care for your patients.
InterX® has been the subject of extensive clinical studies conducted in various countries, including the United States, Great Britain, Italy, Russia, and Australia. These studies have focused on measuring the effectiveness of InterX in reducing pain levels. In addition to pain reduction, several studies have also assessed the impact on pain medication usage and hospitalization duration. To ensure the highest level of research quality, we have selected and compiled the studies that meet rigorous criteria: they are controlled, randomized, involve 60 or more patients, and have been published in reputable scientific journals. Below, you will find detailed information on these selected studies, providing you with valuable insights into the robust evidence supporting the efficacy of InterX in pain management.
2019 Treatment of Low-Grade Lateral Ankle Sprain
2017 Treatment of Chronic Plantar Fasciitis
2016 Chronic Regional Pain Syndrome (CRPS)
2015 Effect of Interactive Neurostimulation Therapy
2011 Total Knee Replacement
2010 Short-Term Recovery with Surgically Repaired Bimalleolar Ankle Fractures
2010 Lower Back Pain
2010 Total Hip Replacement
2007 Trochanteric Fracture of the Femur
2007 InterX Therapy Improving the Condition of Facial Photoaging
2005 Pain Reduction in the Severe Chronic Orthopedic Patients
2009 Recurrent Sinusitis
2007 Transected Medial Collateral Ligament
2005 Unsolved Sports Injuries to Knee
Criteria-Based Management of an Acute Multi-structure Knee Injury in a Professional Football Player: A Case Report
Total Knee and Total Hip Arthroplasty: a Randomized Placebo-Controlled Trial
Indicators of Connective Tissue Healing and Anti-inflammatory Activity using NIN
Product Review: Dr. Tiziano Marovino, DPT, MPH, DAIPM
References
1 Gorodetskyi I G, Gorodnichenko A I, Tursin P S, Reshetnyak V K, Uskov, O N: Non-invasive interactive Neurostimulation in the post-operative recovery of patients with a trochanteric fracture of the femur. J Bone Joint Surg [Br]2007;89-B:1488-94.
2 Maale G: The effect of the InterX 5000 on pain reduction in the severe chronic orthopedic patient. Presented at International Congress of Technology in Arthroplasty, Kyoto, Japan, September 29-October 2, 2005
3 I. G. Gorodetskyi et al, The effects of non-invasive, interactive Neurostimulation on pain and edema during post-surgical rehabilitation following internal fixation of unstable bi-malleolar ankle fractures, Presented as a poster by Dr James Dillard at the IASP 2008, Glasgow, Scotland. Accepted for publication Dec 2009, Journal of Foot and Ankle Surgery
4 Jan Magnus Bjordal, Mark I. Johnson, Anne Elisabeth Ljunggreen; Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption. A meta-analysis with assessment of optimal treatment parameters for postoperative pain
European Journal of Pain 7 (2003) 181-188
5 Melzack R: Prolonged relief of pain by brief, intense transcutaneous somatic stimulation. Pain. 1975;1: 357-373.
6 Somers D, Clemente F R, TENS for the management of neuropathic pain: The effects of frequency and electrode position on prevention of allodynia in a rat model of CRPS type II, Phys Ther, Vol. 86, no.5, 2006: pg 698-709
7 Breit R, Van der Wall H, Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Relief After Total Knee Arthroplasty, The Journal of Arthroplasty Vol. 19 No. 1 2004
8 Carroll D, Tramer M, McQuay H, Nye B, Moore A. Randomization is important in studies with pain outcomes: Systematic review of transcutaneous electrical nerve stimulation in acute postoperative pain. British Journal of Anaesthesia 1996; 77:798-803
9 Walsh D. Trans cutaneous electrical nerve stimulation. In Acupuncture and Related Techniques in Physical Therapy. Eds. Hopwood V, Lovesey M, Mokone S. New York: Churchill Livingston; 1997: 111 – 118.
10 Schultz SP, Driban JB, and Swanik CB. The evaluation of electrodermal properties in the identification of myofascial trigger points. Arch Phys Med Rehabil. 2007;88(6): 780-784.
11 Agatha P. Colbert, Jinkook Yun, Adrian Larsen, Tracy Edinger, William L. Gregory and Tran Thong,, Skin Impedance Measurements for Acupuncture Research: Development of a Continuous Recording System. eCAM 2008 5(4):443-450; doi:10.1093/ecam/nem060
12 Korr, I.M., H.M. Wright and J.A. Chace. Cutaneous patterns of sympathetic activity in clinical abnormalities of the musculoskeletal system. Acta Neuroveg, 25:589-606, 1964
13 Zang Hee Cho Ph.D. Neuro-Acupuncture, Volume 1: Neuroscience Basics ISBN: 9780970645517; Calif: Q-Puncture Inc; 2001
14 Lee KH, Chung JM, Willis WD. Inhibition of primate spinothalamic tract cells by TENS. J Neurosurg. 1985; 62: 276-287
15 Linda S. Chesterton, Nadine E. Foster, Christine C. Wright, G. David Baxter and Panos Barlas
Effects of TENS frequency, intensity and stimulation site parameter manipulation on pressure pain thresholds in healthy human subjects
Pain, Volume 106, Issues 1-2, November 2003, Pages 73-80
16 Garrison DW, Foreman RD: Effects of prolonged transcutaneous electrical nerve stimulation (TENS) and variation of stimulation variables on dorsal horn cell activity, Eur J Phys Med Rehabil 6:87-94, 1997
17 Reilly JP, Applied Bioelectricity: From Electrical Stimulation to Electropathology, 1998 Springer-Verlag NY. pg 130 and 233
18 Christie Q. Huang, Robert K. Shepherd Reduction in excitability of the auditory nerve following electrical stimulation at high stimulus rates: Varying Effects of electrode surface area Hearing Research 146 (2000) 57-71
19G Pyne-Geithman G, Clark J F, InterX elicits significantly greater physiological response than TENS: Lymphocyte metabolism and Cytokine production. Presented as a poster at IASP 2010, Montreal, Canada. Aug. 29th 2010.
20 Han J S, Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neurosciences, Vol. 26, No.1, January 2003
21 Hamza, M.A. et al. (1999) Effect of the frequency of transcutaneous electrical nerve stimulation on the postoperative opioid analgesic requirement and recovery profile. Anesthesiology 91, 1232-1238
22 Chandran P, Sluka KA. Development of opioid tolerance with repeated transcutaneous electrical nerve stimulation administration. Pain. 2003;102:195-201
23 Josimari M. DeSantana, PhD, Valter J. Santana-Filho, MSc, Kathleen A. Sluka, PhD: Modulation Between High- and Low-Frequency Transcutaneous Electric Nerve Stimulation Delays the Development of Analgesic Tolerance in Arthritic Rats Arch Phys Med Rehabil Vol 89, April 2008: pg 754-760
“Any sufficiently advanced technology is indistinguishable from magic.”
Arthur C. Clarke, 1962
“Witchcraft to the ignorant…. Simple science to the learned”
Leigh Brackett, 1942