--- title: InterX Clinical Studies | Evidence-Based Pain Relief Research description: Explore clinical studies on InterX Therapy, showcasing non-invasive neurostimulation, pain reduction, and research-backed effectiveness in global trials. --- [Skip to content](https://interx.com/clinical-studies#main-content) - [Contact Us](https://interx.com/contact-us) - [Our Products](https://interx.com/interx-devices-and-electrodes) - [Request A Quote](https://interx.com/contact-us) [![logo white](https://interx.com/hs-fs/hubfs/logo%20white.png?width=3000&height=1000&name=logo%20white.png) ![logo blue](https://interx.com/hs-fs/hubfs/logo%20blue.png?width=3000&height=1000&name=logo%20blue.png)](https://www.interx.com/) - How It Works - [Interactive Neurostimulation](https://interx.com/neurostimulation-technology) - [Top 10 Reasons for InterX](https://interx.com/reasons-to-use-interx) - [FAQ](https://interx.com/faq) - [Testimonials](https://interx.com/testimonials) - Devices & Electrodes - [InterX Products](https://interx.com/interx-devices-and-electrodes) - [Repairs & Product Lifetime](https://interx.com/repairs-product-lifetime) - [Clinical Studies](https://interx.com/clinical-studies) - Providers - [Military](https://interx.com/pain-relief-for-military) - [Health Care Providers](https://interx.com/health-care-providers) - [Prescribing InterX](https://interx.com/hubfs/InterX-Prescription-Form.pdf) - How it is Used - [Treating Acute Pain](https://interx.com/acute-pain-relief) - [Treating Chronic Pain](https://interx.com/chronic-pain-relief) - [Treating Sports Injuries](https://interx.com/en/athlete-recovery) - [Treating Post-Surgical](https://interx.com/post-surgical-pain-relief) - [REQUEST A QUOTE](https://interx.com/contact-us) # Clinical Studies As a healthcare professional, you need a higher level of proof than your patient. Here we discuss how InterX® is different, certifications, and clinical studies. ### How InterX® Therapy is Unique InterX® has US, EU, and Australian patents on our technology. Here are some key words within these patents which discuss our uniqueness: | | "Neuro Stimulation": This means stimulation of nerves in cases where the signal to the brain has been interrupted. Another definition "helping the nervous system to remember." | | --- | --- | | | "Non-invasive", "transcutaneous": This means that the electrical signal to the brain travels along the exterior of the skin, which can tingle sometimes. Most other medical devices send their electrical current through the body, which can be painful. A higher level of electrical stimulation is possible when current travels across the skin. | | | "Self-directing": InterX®devices tell you the location of the best spot on the skin area to treat. | | | "Multiple devices and accessories". Treatment with multiple devices and accessories accelerates the healing process. |   #### Clinical Studies A number of InterX® clinical studies have been done in the U.S., Great Britain, Italy, Russia, and Australia. All measured pain reduction. Several also measured reduction in pain medication and length of hospitalization required. Shown below in detail are those studies which meet a higher level of research quality. Controlled, Randomized, 60 or more patients, Published. | ![cov200h](https://interx.com/hs-fs/hubfs/cov200h.gif?width=154&height=200&name=cov200h.gif) | #### Noninvasive Interactive Neurostimulation Therapy for the Treatment of Low-Grade Lateral Ankle Sprain Improves the Short-Term Recovery and Return to Sport: A Prospective, Randomized Controlled Trial | | --- | --- | Country Italy Clinical Evidence 1 InterX® has been used by athletic trainers around the world to shorten time of injury recovery. | **Improvements Measured** YES \| Reduction in Pain YES \| Reduction in Medication | | --- | [READ MORE](https://www.jfas.org/article/S1067-2516%2818%2930413-7/fulltext) | ![cov200h](https://interx.com/hs-fs/hubfs/cov200h.gif?width=154&height=200&name=cov200h.gif) | #### Use of Noninvasive Interactive Neurostimulation to Improve Short-Term Recovery in Patients with Surgically Repaired Bimalleolar Ankle Fractures: A Prospective, Randomized Clinical Trial | | --- | --- | Country Russia Clinical Evidence 1 | **Improvements Measured** YES \| Reduction in Pain YES \| Reduction in Medication YES \| Increased Range of Motion YES \| Reduced Edema | | --- | [READ MORE](https://www.jfas.org/article/S1067-2516(10)00194-8/abstract) | ![cov200h](https://interx.com/hs-fs/hubfs/cov200h.gif?width=154&height=200&name=cov200h.gif) | #### Treatment of Chronic Plantar Fasciitis with Noninvasive Interactive Neurostimulation: A Prospective Randomized Controlled Study | | --- | --- | Country Italy Clinical Evidence 2 Tiziano Marovino (DPT,MPH, DAIPM), writing in the October 2020 issue of Practical Pain Management (link below) is in the process of evaluating the InterX 5002 device, and describes his efforts to recruit patients for a trial group with both the InterX device and a sham device to control for placebo. He states: “it is important to note that it was next to impossible to recruit patients who had experienced InterX prior to our receiving the sham unit into the comparative trial because they simply said their sessions were too valuable and did not want to risk not getting the actual treatment. As a result we had to recruit patients who were unfamiliar with the device for our comparative trial…” | **Improvements Measured** YES \| Reduction in Pain YES \| Reduction in Medication YES \| Patient Satisfaction | | --- | [READ MORE](https://www.jfas.org/article/S1067-2516(17)30158-8/abstract) | ![clinicaldoc3](https://interx.com/hs-fs/hubfs/clinicaldoc3.jpg?width=154&height=204&name=clinicaldoc3.jpg) | #### Non-invasive Interactive Neurostimulation (InterX®) Reduces Acute Pain in Patients Following Total Knee Replacement Surgery: A Randomized, Controlled Trial | | --- | --- | Country UK 61 patient study Clinical Evidence Level Not Listed Results: The effects varied slightly between male and female patients. Males took more medication than females in both the active and the sham groups. However, there was a reduction of medication in the active groups compared to sham. While still maintaining a low pain score comparable with sham patients taking more medication, male patients in the active group reduced their medication intake by 34% and female patients reduced their medication intake by 16%. Patients in the active group were discharged on average 1.2 days earlier than the sham group. We conclude that this technology warrants further investigation and there is use for InterX® in the management of pain after total hip arthroplasty. The financial implications of reduced rehabilitation time are of significant value as healthcare costs come under greater scrutiny and pressures. | **Improvements Measured** YES \| Reduction in Pain YES \| Reduction in Medication YES \| Increased Range of Motion YES \| Reduced Edema | | --- | [READ MORE](https://pmc.ncbi.nlm.nih.gov/articles/PMC3182948/) | ![Bone-and-joint-journal](https://interx.com/hs-fs/hubfs/Bone-and-joint-journal.png?width=154&height=204&name=Bone-and-joint-journal.png) | #### Non-invasive interactive neurostimulation in the post operative recovery of patients with a trochanteric fracture of the femur | | --- | --- | Country Russia 61 patient study Clinical Evidence Level Not Listed [This 60 patient study](https://web.archive.org/web/20220713184150/https://pubmed.ncbi.nlm.nih.gov/17998187/) showed improvements in pain, walking, sleep, enjoyment of life, mood, and overall assessment of outcome by an orthopedic surgeon. | **Improvements Measured** YES \| Reduction in Pain YES \| Reduction in Medication YES \| Patient Satisfaction | | --- | [READ MORE](https://boneandjoint.org.uk/Article/10.1302/0301-620X.89B11.19352) ## Transform Pain Relief With InterX Therapy While Growing Your Practice ## [![BECOME AN AFFILIATE](https://hubspot-no-cache-na2-prod.s3.amazonaws.com/cta/default/39874422/interactive-189528006564.png)](https://interx.com/hs/cta/wi/redirect?encryptedPayload=AVxigLJPtQCMTWK%2BV6mW42s9TSAr0JKi52y7aVldzUl076%2FqPO4cor7jSO8QSe6vqx8KUun46VMom6GKoNcDmlypsoBv%2FeciWfwMFIJMSyWIc2dMuE2enSkzskolEjC%2FFj1SJzCgbtVEfad4ZyUMKxd1VHLVt4G2bpFhtMCrYasPMv8UWZfQyndM%2BBJTaudfTuAg3wiijDq8z%2BwZCHYaZKykJ63McXnUUyVUv3rV%2FZ8%3D&webInteractiveContentId=189528006564&portalId=39874422) ![Become an InterX Affiliate](https://interx.com/hubfs/Become%20an%20%20Affiliate%20(2).png) \*The InterX® Neurostimulation System is patented technology for the devices and the accessory electrodes. It is FDA cleared for symptomatic relief and management of chronic intractable pain, and adjunctive treatment in the management of post-surgical and post-traumatic pain. InterX is an ISO13485 registered company. CSA certified. [Supplier Quality Requirements](https://interx.com/hubfs/MST-016-Rev-A-Supplier-Quality-Requirements.pdf) [One Year Warranty Policy](https://interx.com/hubfs/MKTG-021-Rev-H-USA-Warranty-Policy.pdf) [Published Research](http://39874422.hs-sites.com/published-research) **CONTACT US** **INTERX TECHNOLOGIES** 3465 Technology Drive Suite A Plano, TX 75074 Sales:  972-807-2808 Customer Service: 972-665-1810 ext. 2 Email: [orders@interx.com](mailto:orders@interx.com)   [![footer-logo-white](https://interx.com/hubfs/footer-logo-white.png)](https://www.interx.com) - [Privacy Policy](https://interx.com/pivacy-policy) © 2026 Copyright © 2024 InterX® | InterX® Trademark is Owned by HTK Enterprises Inc | All Rights Reserved